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Akilashree, S.
- A Study on Neuropathic Pain:Causes, Grading System, Mechanism-A Review
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1 Department of Bio-Engineering, School of Engineering, Vels Institute of Science, Technology and Advanced Studies, IN
1 Department of Bio-Engineering, School of Engineering, Vels Institute of Science, Technology and Advanced Studies, IN
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Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3125-3132Abstract
Neuropathic pain, the type of pain condition which is caused by the specific nociceptors and is very different from the regular pain. The pain caused is highly intolerable to patients as the pain can be evoked by gentle touch, wind, clothes pressure and puts a great challenge to proceed with day to day activities. The treatments for the neuropathic pain reduces the production of neurotransmitters to some extent which be the cause of intolerable pain, but the faster disease progression is the main concern which can be sorted out by earlier prediction. The efficient grading system is required to differentiate the neuropathic pain condition and to initiate the treatment quickly after the onset of disease. The grading factors give the actual cause, location and the progression of pain. Understanding the mechanism behind the neuropathic pain is very important to carry out the drug formulation, effects of drugs, and distinguishing neuropathic pain from the regular induced pain. It is also required to initiate the treatment shortly after the onset of disease. Here, this review explains about the grading system of neuropathic pain, causes of pain, mechanism and the wide range of drugs involved in the treatment of neuropathic pain.Keywords
Nociceptors, Neuropathic Pain, Neurotransmitters.
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- In Silico Homology Modeling of Presenilin 2- Therapeutic Target for Alzheimer’s Disease
Abstract Views :396 |
PDF Views:0
Authors
Sowmya Hari
1,
S. Akilashree
1
Affiliations
1 Department of Bio-Engineering, School of Engineering, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-600117, Tamilnadu, IN
1 Department of Bio-Engineering, School of Engineering, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-600117, Tamilnadu, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3405-3409Abstract
Alzheimer’s disease is a neurodegenerative disorder which is caused by several mutations in causative proteins like Amyloid Precursor Protein (APP), Presenilin1 (PSEN1), and Presenilin2 (PSEN2). Mutations in presenilin 2 lead to the overproduction of amyloid beta peptide which gets accumulated in the brain and causes neuron death. This result in Early Onset Alzheimer’s disease (EOAD) and there are around 17 mutations in presenilin 2 results in this disease condition. There are 3 isoforms of PSEN2 which are normally found in the cells. Three dimensional structure of presenilin 2 has not been determined; hence, in this study the structure of presenilin 2 was predicted using homology modeling. The 3dimensional structures are modeled using Modeller9.20, Swiss Model and Geno3D. The structures are validated using PROCHECK. The structure of Swiss Model was found to be more reliable with fewer amino acids in the disallowed region, followed by Modeller9.0 and Geno3D. These structures will be fundamental in determining the crystal structure of presenilin 2 and for drug discovery.Keywords
Homology Modeling, Presenilin 2, Alzheimer’s Disease, Modeller9.20, Swiss Model, Geno3D.References
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